Targeting N-cadherin Increases Vascular Permeability and Differentially Activates AKT in Melanoma
نویسندگان
چکیده
منابع مشابه
Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma.
OBJECTIVE We investigate the mechanism through which N-cadherin disruption alters the effectiveness of regional chemotherapy for locally advanced melanoma. BACKGROUND N-cadherin antagonism during regional chemotherapy has demonstrated variable treatment effects. METHODS Isolated limb infusion (ILI) with melphalan (LPAM) or temozolomide (TMZ) was performed on rats bearing melanoma xenografts...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 2015
ISSN: 0003-4932
DOI: 10.1097/sla.0000000000000635